Muhamad Yusuf Khan Khattak (18 November 1917 – 29 July 1991) was a Pakistan movement activist. A scion of one of the most influential families in Khyber-Pakhtunkhwa, he was a son of Khan Bahadur Kuli Khan Khattak, and brother to former Governor Aslam Khattak, Lt Gen Habibullah Khan and Kulsom Saifullah Khan, Yusuf Khattak was a Pakistan movement activist against the Khyber-Pakhtunkhwa (then NWFP) Congress government under Dr Khan Sahib. A close confidante of Liaqat Ali Khan he became Secretary General of the Muslim League after partition. However, he fell out with Muslim League Chief Minister Abdul Qayyum Khan, who actively organised a campaign to oust him and his colleagues like Barrister Khan Saifullah Khan, from any role in provincial politics.
He was then elected Secretary General of the Provincial Muslim League, Khyber-Pakhtunkhwa in 1949. He was soon elevated to the prominent position of Secretary General of All Pakistan Muslim League the same year thereby succeeding Liaquat Ali Khan, Prime Minister of Pakistan as Secretary General of the League.
Frequently in the opposition, he was elected the leader of the opposition in the National Assembly and was a prominent leader in the campaign of Fatima Jinnah against Field Marshal Ayub Khan’s military government.
A prominent critic of Khan Abdul Ghaffar Khans Pakhtunistan policy, he also rejected the National Awami Party’s claim to be the sole representative of Pashtuns.
Reconciling with Qayyum Khan before the bye elections 1971 election, he joined the Pakistan Muslim League-Qayyum faction and contested and won the election from Qayyum Khan’s vacated Peshawar seat.
As part of Qayyum Khan’s alliance with the Pakistan Peoples Party, Yusuf Khattak was appointed Federal Minister for Fuel, Power and Natural Resources in Prime Minister Zulfiqar Ali Bhutto’s Cabinet. He was re-elected to his seat in the 1977 election despite the Qayyum League’s rout.
In 1990 the Government of Pakistan gave him a gold medal for his services to Pakistan.